Our working model of CNS myelin wrapping, based on Snaidero et al., 2014 (M Simons’ group; doi: 10.1016/j.cell.2013.11.044.) and our own observations on the cytosolic spaces in myelin (Edgar et al., 2021; doi: 10.1111/joa.13577. Epub 2021 Oct 28.). Video: Eleanor McGowan, Julia Edgar & Robert Insall.

The Axo-Glial Research Group studies the functions of the cells that form myelinated axons in the central nervous system. Myelinated axons are injured in multiple sclerosis (MS), stroke, Alzheimer’s disease, motor neuron disease and several other neurodegenerative conditions. We aim to understand why myelinated axons are so susceptible and how we might protect them.

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