Publications
The 3D representation of beta tubulin 4 localisation in myelin (blue or white) in relation to the axon (grey) was created by Eleanor McGowan from tracing individual z steps of immunostained myelinating cell cultures, by Julia Edgar. Two adjacent paranodes, separated by a node of Ranvier, are visible on the far left. From Edgar et al., J. Anat. 2021
Mot AI, Li Y, Dibaj P, Tzvetanova ID, Gerwig UC, Bogale TA, Goebbels S, Möbius W, Bergles DE, Morrison BM, Rothstein JD, Cleveland DW, Edgar JM, Nave KA.bioRxiv [Preprint]. 2026 Jun 11:2026.06.09.731100. doi: 10.64898/2026.06.09.731100.PMID: 42327318
An activity-modulated transport route across myelin (TRAM) for motor-driven organelle transfer.
Chapple KJ, et al (2026) Nature Neurosci. in press
Gutierrez-Quintana R, Montague P, Rupp A, Leeb T, Penderis J, Byrne N, Gonzalo-Nadal V, August B, Mullin M, Barrie J, Edgar JM, Duncan ID, McLaughlin M.Proc Natl Acad Sci U S A. 2026 Feb 24;123(8):e2523008123. doi: 10.1073/pnas.2523008123. Epub 2026 Feb 17.PMID: 41701830
Microvascular pathology in the spinal cord of severe spinal muscular atrophy patients.
Allardyce H, Lanz H, Lawrence BD, Crawford TO, Sumner CJ, Parson SH.Acta Neuropathol Commun. 2026 Feb 15;14(1):65. doi: 10.1186/s40478-026-02232-y.PMID: 41692783
Schneeberger S, Kim SJ, Geesdorf MN, Friebel E, Eede P, Jendrach M, Boltengagen A, Braeuning C, Ruhwedel T, Hülsmeier AJ, Gimber N, Foerster M, Obst J, Andreadou M, Mundt S, Schmoranzer J, Prokop S, Kessler W, Kuhlmann T, Möbius W, Nave KA, Hornemann T, Becher B, Edgar JM, Karaiskos N, Kocks C, Rajewsky N, Heppner FL.Nat Aging. 2025 Apr;5(4):622-641. doi: 10.1038/s43587-025-00816-2. Epub 2025 Mar 13.PMID: 40082619
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.
Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich R, Nave KA, Stassart RM.Nat Neurosci. 2023 Jul;26(7):1218-1228. doi: 10.1038/s41593-023-01366-9. Epub 2023 Jun 29.PMID: 37386131
Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model.
de Almeida MMA, et al. (2023) Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model. Stem Cell Rep. doi: 10.1016/j.stemcr.2022.12.001
Steyer AM, et al. (2023) Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag. Glia.
Baldacchino, K. et al., (2022) Myelinated axons are the primary target of hemin-mediated oxidative damage in a model of the central nervous system. Exp. Neurol. doi: 10.1016/j.expneurol.2022.114113
SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection.
Crawford CL, Antoniou C, Komarek L, Schultz V, Donald CL, Montague P, Barnett SC, Linington C, Willison HJ, Kohl A, Coleman MP, Edgar JM.Front Mol Neurosci. 2022 Apr 13;15:860410. doi: 10.3389/fnmol.2022.860410. eCollection 2022.PMID: 35493328
Edgar JM, McGowan E, Chapple KJ, Möbius W, Lemgruber L, Insall RH, Nave KA, Boullerne A.J Anat. 2021 Dec;239(6):1241-1255. doi: 10.1111/joa.13577. Epub 2021 Oct 28.PMID: 34713444
Berghoff, S. A. et al. (2021) Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice. Cell Rep. doi: 10.1016/j.celrep.2021.109889
Schultz, V. et al., (2021) Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: implications for CNS complications. Glia doi: 10.1002/glia.24010
Berghoff, S. A. et al., (2021) Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nature Neuroscience 24(1):47-60 doi: 10.1038/s41593-020-00757-6
Hayden, L. et al. (2020) Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis. Acta Neuropathologica Communications, 8, 135. doi: 10.1186/s40478-020-01011-7
Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. doi: 10.1126/sciadv.aax6328
Gruenenfelder, F. I. et al. (2020) Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain, 143(5) (doi: 10.1093/brain/awaa080) (PMID: 32419025)
Bryden, S. R. et al. (2020) Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12(527), eaax2421. (doi: 10.1126/scitranslmed.aax2421) (PMID:31969486)
Thümmler, K. et al. (2019) Polarizing receptor activation dissociates Fibroblast Growth Factor 2 mediated inhibition of myelination from its neuroprotective potential. Acta Neuropathologica Communications, 7, 212. (doi: 10.1186/s40478-019-0864-6) (PMID:31856924) (PMCID:PMC6923900)
Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi: 10.12688/f1000research.16802.1) (PMID:31069065) (PMCID:PMC6489523)
Wilder-Smith, A. et al. (2019) ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. Global Health Action, 12(1), 1666566. (doi: 10.1080/16549716.2019.1666566) (PMID:31640505) (PMCID:PMC6818126)
Stassart, R. M., Möbius, W., Nave, K.-A. and Edgar, J. M. (2018) The axon-myelin unit in development and degenerative disease. Frontiers in Neuroscience, 12, 467. (doi: 10.3389/fnins.2018.00467) (PMID:30050403) (PMCID:PMC6050401)
Bahey, N. G., Gadalla, K. K.E. , McGonigal, R., Bailey, M. E.S. , Edgar, J. M. and Cobb, S. R. (2017) Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome. Neuroscience, 358, pp. 261-268. (doi: 10.1016/j.neuroscience.2017.06.061)
Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi: 10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)
Goebbels, S. et al. (2017) A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), pp. 10-15. (doi: 10.1038/nn.4425) (PMID:27775720)
Berghoff, S. A. et al. (2017) Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nature Communications, 8, 14241. (doi: 10.1038/ncomms14241) (PMID:28117328) (PMCID:PMC5286209)
Lindner, M. and Thümmler, K. et al. (2015) Fibroblast growth factor signaling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9 environment by Fibroblast Growth Factor 9. Brain, 2015(138), pp. 1875-1893. (doi: 10.1093/brain/awv102) (PMID:25907862)
Deighton, R. F., Le Bihan, T., Martin, S. F., Gerth, A. M. J., McCulloch, M., Edgar, J. M. , Kerr, L. E., Whittle, I. R. and McCulloch, J. (2014) Interactions among mitochondrial proteins altered in glioblastoma. Journal of Neuro-Oncology, 118(2), pp. 247-256. (doi: 10.1007/s11060-014-1430-5)
Snaidero, N. et al. (2014) Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell, 156(1-2), pp. 277-290. (doi: 10.1016/j.cell.2013.11.044)
Ioannidou, K., Anderson, K. I., Strachan, D., Edgar, J. M. and Barnett, S. C. (2014) Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques. BMC Neuroscience, 15(1), p. 59. (doi: 10.1186/1471-2202-15-59)
Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)
de Monasterio-Schrader, P., Patzig, J., Möbius, W., Barrette, B., Wagner, T.L., Kusch, K., Edgar, J.M. , Brophy, P.J. and Werner, H.B. (2013) Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. Glia, 61(11), pp. 1832-1847. (doi: 10.1002/glia.22561)
Barrette, B., Nave, K.-A. and Edgar, J.M. (2013) Molecular triggers of neuroinflammation in mouse models of demyelinating diseases. Biological Chemistry, 394(12), (doi: 10.1515/hsz-2013-0219)
Franklin, R.J.M., ffrench-Constant, C., Edgar, J.M. and Smith, K.J. (2012) Neuroprotection and repair in multiple sclerosis. Nature Reviews Neurology, 8(11), pp. 624-634. (doi: 10.1038/nrneurol.2012.200)
Gutierrez Quintana, R. , Edgar, J. , Wessmann, A., Cherubini, G.B. and Penderis, J. (2012) The cutaneous trunci reflex for localising and grading thoracolumbar spinal cord injuries in dogs. Journal of Small Animal Practice, 53(8), pp. 470-475. (doi: 10.1111/j.1748-5827.2012.01244.x) (PMID:22845846)
Funfschilling, U. et al. (2012) Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature, 485(7399), pp. 517-521. (doi: 10.1038/nature11007)
Ioannidou, K., Anderson, K.I., Strachan, D., Edgar, J.M. and Barnett, S.C. (2012) Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE, 7(1), e30775. (doi: 10.1371/journal.pone.0030775)
Ip, C.W. et al. (2012) Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. PLoS ONE, 7(8), e42554. (doi: 10.1371/journal.pone.0042554) (PMID:22905147) (PMCID:PMC3414455)
Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi: 10.1002/nbm.1700)
Gruenenfelder, F.I., Thomson, G., Penderis, J. and Edgar, J.M. (2011) Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease. Journal of Anatomy, 219(1), pp. 33-43. (doi: 10.1111/j.1469-7580.2011.01363.x)
Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi: 10.1002/glia.21043)
Edgar, J.M. , McCulloch, M.C., Montague, P., Brown, A., Thilemann, S., Pratola, L., Gruenenfelder, F.I., Griffiths, I. and Nave, K.A. (2010) Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease. EMBO Molecular Medicine, 2(2), pp. 42-50. (doi: 10.1002/emmm.200900057)
Hogan, V., White, K., Edgar, J. , McGill, A., Karim, S., McLaughlin, M. , Griffiths, I., Turnbull, D. and Nichols, P. (2009) Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal of Neuroscience Research, 87(2), pp. 452-459. (doi: 10.1002/jnr.21867)
Edgar, J. M. and Nave, K. A. (2009) The role of CNS glia in preserving axon function. Current Opinion in Neurobiology, 19(5), pp. 498-504. (doi: 10.1016/j.conb.2009.08.003)
Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi: 10.1002/glia.20893)
Morfini, G.A. et al. (2009) Axonal Transport Defects in Neurodegenerative Diseases. Journal of Neuroscience, 29(41), pp. 12776-12786. (doi: 10.1523/JNEUROSCI.3463-09.2009)
Wang, E., Dimova, N., Sperle, K., Huang, Z., Lock, L., McCulloch, M., Edgar, J. , Hobson, G. and Cambi, F. (2008) Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Experimental Neurology, 214(2), pp. 322-330. (doi: 10.1016/j.expneurol.2008.09.001)
Edgar, J.M. , McCulloch, M.C., Thomson, C.E. and Griffith, I.R. (2008) Distribution of mitochondria along small-diameter myelinated central nervous system axons. Journal of Neuroscience Research, 86(10), pp. 2250-2257. (doi: 10.1002/jnr.21672)
Edgar, J. (2007) Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion. Cell and Tissue Research, 329(3), pp. 515-527.
Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M., Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi: 10.1002/glia.20465)
McLaughlin, M., Karim, S., Montague, P., Barrie, J., Kirkham, D., Griffiths, I. and Edgar, J. (2007) Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochemical Research, 32, pp. 167-176. (doi: 10.1007/s11064-006-9122-y)
da Costa, N., Edgar, J. , Ooi, P., Su, Y., Meissner, J. and Chang, K. (2007) Calcineurin differentially regulates genes in oxidative muscle fibre type fast myosin heavy chain conversion. Cell and Tissue Research, 329, pp. 515-527. (doi: 10.1007/s00441-007-0441-3)
Ooi, P., da Costa, N., Edgar, J. and Chang, K. (2006) Porcine congenital splayleg is characterised by muscle fibre atrophy associated with relative rise in MAFbx and fall in P311 expression. BMC Veterinary Research, 2(1), p. 23. (doi: 10.1186/1746-6148-2-23)
Andrews, H., White, K., Thomson, C., Edgar, J., Bates, D., Griffiths, I., Turnbull, D. and Nichols, P. (2006) Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the shiverer mouse. Journal of Neuroscience Research, 83, pp. 1533-1539. (doi: 10.1002/jnr.20842)
Fowler, J., Edgar, J., Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi: 10.1002/jnr.20859)
McLaughlin, M., Barrie, J., Karim, S., Montague, P., Edgar, J., Kirkham, D., Thomson, C. and Griffiths, I. (2006) Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53, pp. 715-722. (doi: 10.1002/glia.20325)
Thomson, C., Hunter, A., Griffiths, I., Edgar, J. and McCulloch, M. (2006) Murine spinal cord explants: A model for evaluating axonal growth and myelination in vitro. Journal of Neuroscience Research, 84, pp. 1703-1715. (doi: 10.1002/jnr.21084)
Montague, P., McCallion, A., Barrie, J., Edgar, J., McLaughlin, M., Davies, R. and Griffiths, I. (2005) Characterization of the murine splice variant Mobp155: Developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia, 50, pp. 80-85. (doi: 10.1002/glia.20155)
Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi: 10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)
Edgar, J. and Garbern, J. (2004) The myelinated axon is dependent on the myelinating cell for support and maintenance: Molecules involved. Journal of Neuroscience Research, 76(5), pp. 593-598. (doi: 10.1002/jnr.20063)
Edgar, J., McLaughlin, M., Barrie, J., McCulloch, M., Garbern, J. and Griffiths, I. (2004) Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropathologica, 107, pp. 331-335. (doi: 10.1007/s00401-003-0808-9)
Yool, D. , Montague, P., McLaughlin, M., McCulloch, M., Edgar, J., Nave, K., Davies, R., Griffiths, I. and McCallion, A. (2002) Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia, 39(3), pp. 256-267. (doi: 10.1002/glia.10103) (PMID:12203392)
Edgar, J.M. , Anderson, T.J. , Dickinson, P.J., Barrie, J.A., McCulloch, M.C., Nave, K.A. and Griffiths, I.R. (2002) Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. Journal of Cell Biology, 158, pp. 719-729. (doi: 10.1083/jcb.200202124)
Edgar, J. (2001) Radial migration in the cerebral cortex is enhanced by signals from thalamus. European Journal of Neuroscience, 13(9), pp. 1745-1754.
Edgar, J. (2001) The fates of cells generated at the end of neurogenesis in developing mouse cortex. Journal of Neurobiology, 48(4), pp. 265-277.
Yool, D. A. , Edgar, J. M. , Montague, P. and Malcolm, S. (2000) The proteolipid protein gene and myelin disorders in man and animal models. Human Molecular Genetics, 9(6), pp. 987-992. (doi: 10.1093/hmg/9.6.987) (PMID:10767322)